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|EPR Techniques:||cw EPR, DEER / PELDOR, pulse EPR|
|Research Areas:||drug development, membrane proteins|
Allosteric drugs have the ability to fine-tune cellular response and direct cell signaling towards a particular pathway for the largest class of druggable proteins, G protein coupled receptors (GPCRs). I use continuous wave and DEER EPR spectroscopies to study GPCRs in the presence of allosteric ligands, to identify the mechanism of the allosteric response, and inform future rational drug design.